KEGG analysis implied that the significantly changed genes were enriched in the PI3K/Akt pathway. To deeper explore molecular mechanisms, the CBD-treated T24 cell transcriptome libraries were established. For example, T24 cells were treated with 12 µM CBD for 48 h, flow cytometry analysis demonstrated that early and late apoptotic cells were accounted for by 49.91%, indicating CBD enhanced cell apoptosis ability. Here, several experiments proved that CBD promoted BC cells (T24, 5637, and UM-UC-3) death. However, the effects of CBD on bladder cancer (BC) and the underlying molecular mechanisms are rarely reported. ![]() ![]() Cannabidiol (CBD), a primary bioactive phytocannabinoid extracted from hemp, is reported to possess potent anti-tumorigenic activity in multiple cancers.
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